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pentobarbital will lower the extent or outcome of mestranol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.Observe Carefully (2)pentobarbital will minimize the extent or impact of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Powerful CYP3A4 inducers may possibly reduce suvore